1416014-99-7Relevant academic research and scientific papers
Synthesis and spectroscopic characterisation of a heterodinuclear iron(III)-copper(II) complex based on an asymmetric dinucleating ligand system
Heims, Florian,Mereacre, Valeriu,Ciancetta, Antonella,Mebs, Stefan,Powell, Annie K.,Greco, Claudio,Ray, Kallol
, p. 4565 - 4569 (2012)
The site-directed generation of a heterodinuclear FeIIICu II complex by using a new asymmetric dinucleating ligand FloH is reported. The iron(III) ion is introduced first on the preferential metal-binding site of the ligand that leads to the formation of the thermodynamically favored five-membered chelate rings upon metal-binding. Copper(II) is introduced in the next step. The stepwise metalation strategy reported here may be extended to the preparation of other heterometallic complexes with the view of avoiding a statistical distribution. Such complexes can offer novel spectroscopic properties, electronic structures, and reactivities in comparison to their homometallic analogues. Copyright
Unsymmetrical binding modes of the HOPNO inhibitor of tyrosinase: From model complexes to the enzyme
Bochot, Constance,Favre, Elisabeth,Dubois, Carole,Baptiste, Benoit,Bubacco, Luigi,Carrupt, Pierre-Alain,Gellon, Gisèle,Hardré, Renaud,Luneau, Dominique,Moreau, Yohann,Nurisso, Alessandra,Réglier, Marius,Serratrice, Guy,Belle, Catherine,Jamet, Hélène
, p. 3655 - 3664 (2013/04/10)
The deciphering of the binding mode of tyrosinase (Ty) inhibitors is essential to understand how to regulate the tyrosinase activity. In this paper, by combining experimental and theoretical methods, we studied an unsymmetrical tyrosinase functional model and its interaction with 2-hydroxypyridine-N-oxide (HOPNO), a new and efficient competitive inhibitor for bacterial Ty. The tyrosinase model was a dinuclear copper complex bridged by a chelated ring with two different complexing arms (namely (bis(2-ethylpyridyl)amino)methyl and (bis(2-methylpyridyl)amino)methyl). The geometrical asymmetry of the complex induces an unsymmetrical binding of HOPNO. Comparisons have been made with the binding modes obtained on similar symmetrical complexes. Finally, by using quantum mechanics/molecular mechanics (QM/MM) calculations, we studied the binding mode in tyrosinase from a bacterial source. A new unsymmetrical binding mode was obtained, which was linked to the second coordination sphere of the enzyme. Copyright
