1416064-69-1

Basic information

• Product Name: C₃₃H₄₃N₃O₃
• CAS NO: 1416064-69-1
• Molecular Weight: 529.723
• Mol File: 1416064-69-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₃H₄₃N₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₃H₄₃N₃O₃(1416064-69-1)
• EPA Substance Registry System: C₃₃H₄₃N₃O₃(1416064-69-1)

Safety Data

• Hazardous Substances Data: 1416064-69-1(Hazardous Substances Data)

Upstream product

• 620-13-3 1-bromomethyl-3-methyl-benzene 
• 90-02-8 salicylaldehyde 
• 351984-86-6 2-((3-methylbenzyl)oxy)benzaldehyde 
• 1416064-31-7 2-(adamantan-1-yl)-N-(2-oxo-2-(piperazin-1-yl)ethyl)acetamide 

Relevant articles and documents

Inhibition of Ebola virus infection: Identification of niemann-pick C1 as the target by optimization of a chemical probe

A high-throughput screen identified adamantane dipeptide 1 as an inhibitor of Ebola virus (EboV) infection. Hit-to-lead optimization to determine the structure-activity relationship (SAR) identified the more potent EboV inhibitor 2 and a photoaffinity labeling agent 3. These antiviral compounds were employed to identify the target as Niemann-Pick C1 (NPC1), a host protein that binds the EboV glycoprotein and is essential for infection. These studies establish NPC1 as a promising target for antiviral therapy.