1416085-72-7

Basic information

• Product Name: ethyl 4-acetamido-3-(trifluoromethyl)benzoate
• Synonyms: ethyl 4-acetamido-3-(trifluoromethyl)benzoate
• CAS NO: 1416085-72-7
• Molecular Weight: 275.227
• Mol File: 1416085-72-7.mol

Chemical Properties

• CAS DataBase Reference: ethyl 4-acetamido-3-(trifluoromethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-acetamido-3-(trifluoromethyl)benzoate(1416085-72-7)
• EPA Substance Registry System: ethyl 4-acetamido-3-(trifluoromethyl)benzoate(1416085-72-7)

Safety Data

• Hazardous Substances Data: 1416085-72-7(Hazardous Substances Data)

Upstream product

• 5338-44-3 ethyl p-acetamidobenzoate 
• 2926-29-6 Langlois reagent 

Relevant articles and documents

Copper-free direct C-H trifluoromethylation of acetanilides with sodium trifluoromethanesulfinate

A copper-free direct C-H ortho trifluoromethylation of electron-deficient 4-substituted acetanilides using Langlois reagent (NaSO2CF3) as the CF3 source in the presence of tert-butyl hydroperoxide (tBuOOH, TBHP) was developed.

Visible-light-induced Pd-catalyzed: Ortho -trifluoromethylation of acetanilides with CF3SO2Na under ambient conditions in the absence of an external photocatalyst

A visible-light-induced Pd-catalyzed ortho-trifluoromethylation of acetanilides with CF3SO2Na was developed. The reaction proceeded smoothly at room temperature in air without any external photocatalyst or additive, providing the desired products in moderate to good yields with good functional group tolerance and regioselectivity.

Preparation 2-trifluoromethyl-4-substituted aniline compounds

The invention relates to a method for preparing 2-trifluoromethyl-4-substituted phenylamine and 2-trifluoromethyl-4-substituted acetanilide. The method for preparing the2-trifluoromethyl-4-substituted phenylamine and 2-trifluoromethyl-4-substituted acetanilide comprises the following main step: in the presence of sodium trifluoromethanesulfonate and tert-butyl hydroperoxide but no metal salt catalyst and under the stirring condition, maintaining a 4-substituted phenylamine compound (concrete structure shown in a formula II is described in the specification) in a reaction medium of mixture composed of dichloromethane and water at the temperature of 0-25 DEG C for 72-120 hours, so that the 2-trifluoromethyl-4-substituted phenylamine target product is obtained. The preparation method provided by the invention has potential commercial value.