141611-10-1

Basic information

• Product Name: D-myo-Inositol-1,4,5-triphosphate (sodium salt)
• Synonyms: D-myo-Inositol-1,4,5-triphosphate (sodium salt);ZVCVTWVBDIPWPZ-ZKVWPJASSA-K
• CAS NO: 141611-10-1
• Molecular Formula: C₆H₉O₁₅P₃*6Na
• Molecular Weight: 486.041073
• Mol File: 141611-10-1.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: D-myo-Inositol-1,4,5-triphosphate (sodium salt)(CAS DataBase Reference)
• NIST Chemistry Reference: D-myo-Inositol-1,4,5-triphosphate (sodium salt)(141611-10-1)
• EPA Substance Registry System: D-myo-Inositol-1,4,5-triphosphate (sodium salt)(141611-10-1)

Safety Data

• Hazardous Substances Data: 141611-10-1(Hazardous Substances Data)

Usage

Uses

D-myo-Inositol 1,4,5-Tris-phosphate Trisodium Salt is used in the preparation of optically active compounds that functions as second messenger in a new intracellular signal transduction systems.

Upstream product

• 114419-09-9 (-)-1L-2,5,6-tri-O-benzyl-1,3,4-tris(dibenzylphospho)-myo-inositol 
• 128119-51-7 C₂₇H₂₇O₁₈P₃ 
• 128119-51-7 C₂₇H₂₇O₁₈P₃ 
• 128119-51-7 C₂₇H₂₇O₁₈P₃ 
• 128119-51-7 C₂₇H₂₇O₁₈P₃ 
• 1312185-55-9 1D-2,3,6-tris-O-(benzyloxymethyl)myoinositol 1,4,5-tris(dibenzyl phosphate) 
• 342789-76-8 (-)-D-3-O-benzyl-2,6-O-bisbenzyloxymethyl-myo-inositol 1,4,5-tris(dibenzyl phosphate) 
• 140840-40-0 C₂₆H₄₀O₈Si 
• 140840-42-2 C₄₀H₇₀O₁₀Si₃ 
• 104873-74-7 1D-1,4,5-tri-O-allyl-3,6-di-O-benzyl-myo-inositol 
• 98925-52-1 (+/-)-5,6-di-O-allyl-1,4-di-O-benzyl-myo-inositol 
• 104873-73-6 1L-5,6-di-O-allyl-1,4-di-O-benzyl-myo-inositol 
• 35949-66-7 (+/-)-1,4-di-O-benzyl-2,3-O-cyclohexylidene-myo-inositol 
• 34361-60-9 1,2:4,5-dicyclohexylidene-myo-inositol 

Relevant articles and documents

Yb(OTf)3-Catalyzed Desymmetrization of myo-Inositol 1,3,5-Orthoformate and Its Application in the Synthesis of Chiral Inositol Phosphates

A variety of inositol phosphates including myo-inositol 1,4,5-trisphosphate, which is a secondary messenger in transmembrane signaling, were selectively synthesized via Yb(OTf)3-catalyzed desymmetrization of myo-inositol 1,3,5-orthoformate using a proline-based chiral anhydride as an acylation precursor. The investigated catalytic system could regioselectively differentiate the enantiotopic hydroxy groups of myo-inositol 1,3,5-orthoformate in the presence of a chiral auxiliary. This key step to generate a suitably protected chiral myo-inositol derivatives is described here as a unified approach to access inositol phosphates.

A type 2 Ferrier rearrangement-based synthesis of d-myo-inositol 1,4,5-trisphosphate

The synthesis of d-myo-inositol 1,4,5-trisphosphate (InsP3) from methyl α-d-glucopyranose, via a type 2 Ferrier rearrangement is reported. A key intermediate in this synthesis possesses orthogonal protecting groups at the 1-, 4- and 5-position, making it a versatile starting point for the synthesis of unnatural InsP3 derivatives. Biological evaluation of the synthetic InsP3 demonstrates that this compound evokes selective Ca2+ release via activation of InsP3 receptors.

Regioselective phosphorylation of vicinal 3,4-hydroxy myo-inositol derivative promoted practical synthesis of D-PtdIns(4,5)P2 and D-Ins(1,4,5)P3

The reactivity of 3 and 4-OH in 3,4-diol myo-inositol derivatives were observed through the phosphorylation, acylation and silylation. The results indicated that 3-OH is much more reactive than 4-OH, giving regiospecifically 3-mono-functionalized products