1416133-10-2

Basic information

• Product Name: 3-(2-chlorophenyl)-4-fluoro-4-(2-nitro-1-phenylethyl)isoxazol-5(4H)-one
• CAS NO: 1416133-10-2
• Molecular Weight: 362.745
• Mol File: 1416133-10-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(2-chlorophenyl)-4-fluoro-4-(2-nitro-1-phenylethyl)isoxazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-chlorophenyl)-4-fluoro-4-(2-nitro-1-phenylethyl)isoxazol-5(4H)-one(1416133-10-2)
• EPA Substance Registry System: 3-(2-chlorophenyl)-4-fluoro-4-(2-nitro-1-phenylethyl)isoxazol-5(4H)-one(1416133-10-2)

Safety Data

• Hazardous Substances Data: 1416133-10-2(Hazardous Substances Data)

Upstream product

• 5153-67-3 nitrostyrene 
• 27025-73-6 3-(2-chloro-phenyl)-2H-isoxazol-5-one 

Relevant articles and documents

Organocatalytic asymmetric one-pot sequential conjugate addition/dearomative fluorination: Synthesis of chiral fluorinated isoxazol-5(4 H)-ones

A facile one-pot sequential conjugate addition/dearomative fluorination transformation of isoxazol-5(4H)-ones with nitroolefins and N- fluorobenzenesulfonimide (NFSI) has been developed. By using a bifunctional chiral tertiary amino-thiourea catalyst, a series of chiral fluorinated isoxazol-5(4H)-ones containing one fluorine-substituted quarternary stereocenter were obtained in high yields with high enantio- and diastereoselectivities. Further transformation of adducts could afford isoxazolidin-5-one derivatives with three contiguous stereocenters.