1416133-39-5

Basic information

• Product Name: 3-benzyloxymethyl-1-(4-C-tert-butyldiphenylsilyloxymethyl-3,5-di-O-benzyl-β-D-ribofuranosyl)thymine
• Synonyms: 3-benzyloxymethyl-1-(4-C-tert-butyldiphenylsilyloxymethyl-3,5-di-O-benzyl-β-D-ribofuranosyl)thymine
• CAS NO: 1416133-39-5
• Molecular Weight: 827.062
• Mol File: 1416133-39-5.mol

Chemical Properties

• CAS DataBase Reference: 3-benzyloxymethyl-1-(4-C-tert-butyldiphenylsilyloxymethyl-3,5-di-O-benzyl-β-D-ribofuranosyl)thymine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-benzyloxymethyl-1-(4-C-tert-butyldiphenylsilyloxymethyl-3,5-di-O-benzyl-β-D-ribofuranosyl)thymine(1416133-39-5)
• EPA Substance Registry System: 3-benzyloxymethyl-1-(4-C-tert-butyldiphenylsilyloxymethyl-3,5-di-O-benzyl-β-D-ribofuranosyl)thymine(1416133-39-5)

Safety Data

• Hazardous Substances Data: 1416133-39-5(Hazardous Substances Data)

Upstream product

• 1300589-63-2 2'-O-acetyl-3',5'-di-O-benzyl-4'-C-(tert-butyldiphenylsilyloxymethyl)-5-methyluridine 
• 3587-60-8 Benzyloxymethyl chloride 
• 1300589-65-4 3',5'-di-O-benzyl-4'-C-(tert-butyldiphenylsilyloxymethyl)-5-methyluridine 

Downstream Products

• 1416133-42-0 3-N-benzyloxymethyl-3',5'-di-O-benzyl-4'-methoxycarbonyl-2'-O-methyl-5-methyluridine 
• 1416133-44-2 5'-O-(4,4'-dimethoxytrityl)-4'-methoxycarbonyl-2'-O-methyl-5-methyluridine 
• 1416133-45-3 3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytrityl)-4'-methoxycarbonyl-2'-O-methyl-5-methyluridine 

Relevant articles and documents

Synthesis of the Methyl Analog of 2′- O,4′- C-Ethylene-Bridged 5-Methyluridine via Intramolecular Radical Cyclization and Properties of Modified Oligonucleotides

The synthesis of 6′S-Me-2′-O,4′-C-ethylene-bridged 5-methyluridine (6′S-Me-ENA-T) was achieved using visible light-mediated stereoselective radical cyclization as a key step. This is the first example of a method for constructing a 2′,4′-bridged structure

Synthesis and duplex-forming ability of oligonucleotides containing 4′-carboxythymidine analogs

Oligonucleotides containing 4′-carboxy-, 4′-methoxycarbonyl-, 4′-carbamoyl-, and 4′-methylcarbamoyl-thymidines, and their 2′-methoxy, 2′-amino or 2′-acetamido analogs were prepared. Their duplex-forming ability with DNA and RNA complements was evaluated by UV melting experiments. Interestingly, 4′-carboxythymidine existing in the S-type sugar conformation was found to lead to an increase in the stability of the duplex formed with RNA complements compared to natural thymidine. The Royal Society of Chemistry 2012.