1416133-89-5

Basic information

• Product Name: JW 642
• Synonyms: JW 642;1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(3-phenoxybenzyl)piperazine-1-carboxylate
• CAS NO: 1416133-89-5
• Molecular Formula: C₂₁H₂₀F₆N₂O₃
• Molecular Weight: 462.3855192
• Mol File: 1416133-89-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 432.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.354±0.06 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• PKA: 6.13±0.10(Predicted)
• CAS DataBase Reference: JW 642(CAS DataBase Reference)
• NIST Chemistry Reference: JW 642(1416133-89-5)
• EPA Substance Registry System: JW 642(1416133-89-5)

Safety Data

• Hazardous Substances Data: 1416133-89-5(Hazardous Substances Data)

Usage

Uses

JW 642 is a highly selective inhibitor of monoacylglycerol lipase (MAGL).

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 920-66-1 1,1,1,3',3',3'-hexafluoro-propanol 
• 114010-96-7 1-(3-phenoxybenzyl)piperazine 

Relevant articles and documents

Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL)

The key hydrolytic enzymes of the endocannabinoid system, fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), are potential targets for various therapeutic applications. In this paper, we present more extensively the results of our previous work on piperazine and piperidine carboxamides and carbamates as FAAH and MAGL inhibitors. The best compounds of these series function as potent and selective MAGL/FAAH inhibitors or as dual FAAH/MAGL inhibitors at nanomolar concentrations. This study revealed that MAGL inhibitors should comprise leaving-groups with a conjugate acid pKa of 8-10, while diverse leaving groups are tolerated for FAAH inhibitors.