1416134-47-8

Basic information

• Product Name: (2S,5R)-ethyl 5-(benzyloxyaMino)piperidine-2-carboxylate
• Synonyms: (2s,5r)-ethyl 5-((benzyloxy)amino)piperidine-2-carboxylate oxalate;(2S,5R)-ethyl 5-(benzyloxyaMino)piperidine-2-carboxylate;2-Piperidinecarboxylic acid, 5-[(phenylmethoxy)amino]-, ethyl ester, (2S,5R)-
• CAS NO: 1416134-47-8
• Molecular Formula: C15H22N2O3
• Molecular Weight: 278.35
• Mol File: 1416134-47-8.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 391.2±52.0 °C(Predicted)
• Appearance: /
• Density: 1.13±0.1 g/cm3(Predicted)
• PKA: 7.47±0.10(Predicted)
• CAS DataBase Reference: (2S,5R)-ethyl 5-(benzyloxyaMino)piperidine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,5R)-ethyl 5-(benzyloxyaMino)piperidine-2-carboxylate(1416134-47-8)
• EPA Substance Registry System: (2S,5R)-ethyl 5-(benzyloxyaMino)piperidine-2-carboxylate(1416134-47-8)

Safety Data

• Hazardous Substances Data: 1416134-47-8(Hazardous Substances Data)

Usage

Description

C₁₅H₂₂N₂O₃, also known as levocetirizine, is a second-generation antihistamine medication used to treat allergies and hay fever. It belongs to a class of drugs that are less sedating than first-generation antihistamines and works by blocking the action of histamine, a substance responsible for allergy symptoms.

Uses

Used in Pharmaceutical Industry:
C₁₅H₂₂N₂O₃ is used as an antihistamine medication for treating allergies and hay fever. It is effective in relieving symptoms such as runny nose, itching, and hives caused by allergic reactions.
Used in Allergy Treatment:
C₁₅H₂₂N₂O₃ is used as a treatment for allergic reactions, providing relief from symptoms like itching, sneezing, and watery eyes. Its less sedating properties make it a preferred choice over first-generation antihistamines.
Available in Oral Tablet and Liquid Form:
C₁₅H₂₂N₂O₃ is available in both oral tablet and liquid forms, making it accessible for various patient needs and preferences.
Common Brand Names:
C₁₅H₂₂N₂O₃ is marketed under brand names such as Xyzal and Levrix, making it a widely recognized and trusted medication for allergy relief.

Upstream product

• 1416134-58-1 ethyl (S)-2-((tert-butoxycarbonyl)amino)-6-(dimethyl(oxo)-λ⁶-sulfanylidene)-5-oxohexanoate 
• 144978-35-8 (S)-ethyl N-tert-butoxycarbonylpyroglutamate 
• 144978-12-1 1-tert-butyl 2-ethyl (2R)-5-oxopyrrolidine-1,2-dicarboxylate 
• 56-86-0 L-glutamic acid 

Downstream Products

• 2064219-13-0 (2R,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid 
• 1174020-25-7 (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid 

Relevant articles and documents

Method of preparing 5R-[(benzyloxy) amino] piperidine-2S-carboxylic acid or a derivative thereof

The present application relates to methods of preparing 5R-[(benzyloxy) amino] piperidine-2S-carboxylic acid or its derivatives in an environment-friendly way. The method uses L-glutamic acid as a starting material, which is first subjected to esterification reaction in the presence of an acidic reagent, and then reacted successively with 2-haloacetate and N-protecting agent, or with N-protecting agent and 2-haloacetate under a basic condition to obtain compound IV; then, the obtained compound IV is subjected to intramolecular condensation into a ring under the action of a strong base to obtain N-protecting group piperidine-5-one-2S-carboxylate (V).

DIAAZABICYCLOOCTANONE DERIVATIVES AS ANTIBACTERIALS

The invention relates to a compound which is a diazabicyclooctanone of Formula (I) or a pharmaceutically acceptable salt thereof: wherein R is as defined herein. The compounds are useful in the treatment of bacterial infection, in particular they are useful in reducing bacterial resistance to antibiotics. They are also useful in the treatment of bacteria which express serine-P-lactamase enzymes, in combination with antibiotics.

MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY

The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R2a, R3, Ra2, Ra4, R