1416141-89-3

Upstream product

• 915410-93-4 1,3-dibromo-5-((4-methoxybenzyl)oxy)-benzene 
• 5876-51-7 5-iodo-1,3-benzodioxole 
• 105-13-5 4-Methoxybenzyl alcohol 
• 1435-51-4 1,3-dibromo-5-fluorobenzene 

Downstream Products

• 1123157-93-6 3-(benzo[1,3]dioxol-5-yl)-5-(thiophen-3-yl)phenol 
• 1261947-54-9 3-(benzo[d][1,3]dioxol-5-yl)-5-bromophenol 
• 1123157-92-5 4-{3-[6-(3-(benzo[1,3]dioxol-5-yl)-5-(thiophen-3-yl)phenoxy)hexyl]-2-(2-ethoxycarbonylethyl)phenoxy}butyric acid ethyl ester 
• 1123155-95-2 4-{3-[6-(3-(benzo[1,3]dioxol-5-yl)-5-(thiophen-3-yl)phenoxy)hexyl]-2-(2-carboxyethyl)phenoxy}butyric acid 
• 1416141-92-8 C₂₅H₂₀O₄S 

Relevant academic research and scientific papers

Process research on a phenoxybutyric acid LTB4 receptor antagonist. Efficient kilogram-scale synthesis of a 3,5-bisarylphenol core

An improved, kilogram-scale synthesis of a LTB4 receptor antagonist is reported. The title compound was prepared in four linear steps (seven steps total) and 54% overall yield. The 3,5-bisarylphenol core was obtained in nearly quantitative yield by the condensation of 1-benzotriazol-1-ylpropan-2-one with a chalcone. Although all the intermediates were oils, no chromatography purification was required.