1416144-06-3Relevant articles and documents
Automated synthesis of sialylated oligosaccharides
Esposito, Davide,Hurevich, Mattan,Castagner, Bastien,Wang, Cheng-Chung,Seeberger, Peter H.
, p. 1601 - 1609 (2013/01/15)
Sialic acid-containing glycans play a major role in cell-surface interactions with external partners such as cells and viruses. Straightforward access to sialosides is required in order to study their biological functions on a molecular level. Here, automated oligosaccharide synthesis was used to facilitate the preparation of this class of biomolecules. Our strategy relies on novel sialyl α-(2→3) and α-(2→6) galactosyl imidates, which, used in combination with the automated platform, provided rapid access to a small library of conjugation-ready sialosides of biological relevance.