1416176-14-1

Basic information

• Product Name: 3-Boc-3-azaspiro[5.5]undecane-9-carbaldehyde
• Synonyms: 3-Boc-3-azaspiro[5.5]undecane-9-carbaldehyde;tert-butyl 9-formyl-3-azaspiro[5.5]undecane-3-carboxylate;3-Boc-3-azaspiro[5.5]undecane-9-carbaldehyde - A10745
• CAS NO: 1416176-14-1
• Molecular Formula: C₁₆H₂₇NO₃
• Molecular Weight: 281.39048
• Mol File: 1416176-14-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Boc-3-azaspiro[5.5]undecane-9-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Boc-3-azaspiro[5.5]undecane-9-carbaldehyde(1416176-14-1)
• EPA Substance Registry System: 3-Boc-3-azaspiro[5.5]undecane-9-carbaldehyde(1416176-14-1)

Safety Data

• Hazardous Substances Data: 1416176-14-1(Hazardous Substances Data)

Usage

General Description

3-Boc-3-azaspiro[5.5]undecane-9-carbaldehyde is a chemical compound with a complex molecular structure. It contains a Boc (tert-butoxycarbonyl) protecting group, a spirocyclic ring system, and a carbaldehyde functional group. The compound's spirocyclic structure makes it useful for pharmaceutical and chemical synthesis, as spirocycles are often found in biologically active compounds and natural products. The Boc protecting group helps to control the reactivity and selectivity of the compound in chemical reactions. The carbaldehyde functional group is a versatile building block for the synthesis of various organic molecules. Overall, 3-Boc-3-azaspiro[5.5]undecane-9-carbaldehyde has potential applications in medicinal chemistry, material science, and chemical research.

Upstream product

• 1416176-13-0 tert-butyl 9-(methoxymethylidene)-3-azaspiro[5.5]undecane-3-carboxylate 
• 873924-08-4 9-oxo-3-azaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester 

Downstream Products

• 1599478-63-3 3-(3-(5-cyclobutoxy-2-fluorophenyl)-3-azaspiro[5.5]undecan-9-yl)propanoic acid 
• 1599479-05-6 ethyl 3-(3-(5-cyclobutoxy-2-fluorophenyl)-3-azaspiro[5.5]undecan-9-yl)propanoate 
• 1416173-83-5 tert-butyl 9-{3-[4-(methanesulfonyl)phenoxy]propyl}-3-azaspiro[5.5]undecane-3-carboxylate 
• 1599478-66-6 C₂₀H₂₅ClF₃NO₃ 

Relevant articles and documents

Design, synthesis and biological evaluation of novel 7-azaspiro[3.5]nonane derivatives as GPR119 agonists

The design and synthesis of a novel class of 7-azaspiro[3.5]nonane GPR119 agonists are described. In this series, optimization of the right piperidine N-capping group (R2) and the left aryl group (R3) led to the identification of compound 54g as a potent GPR119 agonist. Compound 54g showed a desirable PK profile in Sprague-Dawley (SD) rats and a favorable glucose lowering effect in diabetic rats.

SUBSTITUTED SPIROPIPERIDINYL COMPOUNDS USEFUL AS GPR120 AGONISTS

The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.