14162-88-0

Basic information

• Product Name: 3-Hydroxy-6-Methyl-2-pyridinecarboxylic acid
• Synonyms: 3-Hydroxy-6-Methyl-2-pyridinecarboxylic acid;3-Hydroxy-6-Methyl-pyridine-2-carboxylic acid;3-Hydroxy-6-Methylpicolinic acid
• CAS NO: 14162-88-0
• Molecular Formula: C₇H₇NO₃
• Molecular Weight: 153.13538
• EINECS: -0
• Mol File: 14162-88-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 228 °C (decomp)
• Boiling Point: 414.4±45.0 °C(Predicted)
• Appearance: /
• Density: 1.393±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.24±0.50(Predicted)
• CAS DataBase Reference: 3-Hydroxy-6-Methyl-2-pyridinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Hydroxy-6-Methyl-2-pyridinecarboxylic acid(14162-88-0)
• EPA Substance Registry System: 3-Hydroxy-6-Methyl-2-pyridinecarboxylic acid(14162-88-0)

Safety Data

• Hazardous Substances Data: 14162-88-0(Hazardous Substances Data)

Usage

General Description

3-Hydroxy-6-Methyl-2-pyridinecarboxylic acid is a chemical compound often used in scientific research, particularly in chemistry and biochemistry fields. As the name indicates, it is an organic compound with a structure derived from pyridinecarboxylic acid, which is a type of heterocyclic aromatic organic compound. It is composed of a six-membered ring containing one nitrogen atom and five carbon atoms, and it is substituted with a hydroxy group at the 3rd position, a methyl group at the 6th position, and a carboxylic acid group at the 2nd position. However, there is little data on it's particular usage, toxicity, or potential benefits or harm to the human body.

Upstream product

• 42097-42-7 3-hydroxy-2-hydroxymethyl-6-methylpyridine 
• 856855-78-2 3-methoxy-2-methoxymethyl-6-methyl-pyridine 
• 934-60-1 6-methyl-2-pyridinecarboxylic acid 
• 727736-69-8 3-hydroxy-6-methylpicolinonitrile 
• 1121-78-4 5-Hydroxy-2-methylpyridine 
• 24207-00-9 3-hydroxy-6-methylpyridine N-oxide 
• 95109-37-8 3-methoxy-6-methyl-pyridine-2-carboxylic acid 

Downstream Products

• 42097-42-7 3-hydroxy-2-hydroxymethyl-6-methylpyridine 
• 1121-78-4 5-Hydroxy-2-methylpyridine 

Relevant articles and documents

A tautomeric ligand enables directed C-H hydroxylation with molecular oxygen

Hydroxylation of aryl carbon-hydrogen bonds with transition metal catalysts has proven challenging when oxygen is used as the oxidant. Here, we report a palladium complex bearing a bidentate pyridine/ pyridone ligand that efficiently catalyzes this reaction at ring positions adjacent to carboxylic acids. Infrared, x-ray, and computational analysis support a possible role of ligand tautomerization from monoanionic (L,X) to neutral (L,L) coordination in the catalytic cycle of aerobic carbon-hydrogen hydroxylation reaction. The conventional site selectivity dictated by heterocycles is overturned by this catalyst, thus allowing late-stage modification of compounds of pharmaceutical interest at previously inaccessible sites.

Oxidation of 3-hydroxy-6-methyl-2-pyridinemethanol by chromium(VI) in acidic aqueous media; kinetic and EPR studies

Kinetics of oxidation of 3-hydroxy-6-methyl-2-pyridinemethanol (hmpol) by CrVI at HClO4 was studied under the pseudo-first-order conditions. The hmpol oxidation products were the appropriate aldehyde (hmpal) and acid (hmpac) coordinated to the chromium(III). The linear dependence of the pseudo-first-order rate constant (kobs) on [hmpol] at 1.0 and 2.0 M HClO4 and a parabolic dependence of kobs on [H+] were established. The apparent activation parameters were determined from the second-order rate constants at 1.0 M HClO4. The presence of the CrII and CrIV intermediates was deduced, based on rate retardation effect caused by O2 and MnII respectively, whereas the presence of CrV was established by EPR. Some correlations between the structure and stability of intermediate chromium(V) complexes have been discussed from EPR spectra, recorded during the redox process.