1416249-55-2Relevant academic research and scientific papers
Attempted Simmon-Smith reaction on β-alkylthio-α,β- unsaturated ketones: A regiospecific synthesis of 2,4-disubstituted thiophenes
Swaroop, Toreshettahally R.,Roopashree, Rangaswamy,Ila, Hiriyakkanavar,Rangappa, Kanchugarakoppal S.
, p. 147 - 150 (2013/02/21)
A new regiospecific route to 2,4-disubstituted thiophenes has been developed through Simmon-Smith reaction on β-methylthio-α,β- unsaturated ketones. Extension of the reaction to β-ethyl/benzylthio- α,β-unsaturated ketones also gave the corresponding 2,4-disubstituted thiophenes in a regiospecific manner. A probable mechanism involving a carbenoid methylene insertion to divalent sulfur followed by intramolecular aldol condensation has been suggested.
