1416249-63-2Relevant academic research and scientific papers
Anti-cancer activity of 2,4-disubstituted thiophene derivatives: Dual inhibitors of lipoxygenase and cyclooxygenase
Rakesh, Kodagahalli S.,Jagadish, Swamy,Swaroop, Toreshettahally R.,Mohan, Chakrabhavi D.,Ashwini, Nanjundaswamy,Harsha, Kachigere B.,Zameer, Farhan,Girish, Kesturu S.,Rangappa, Kanchugarakoppal S.
, p. 462 - 472 (2015/07/27)
2,4-Disubstituted thiophene derivatives were synthesized and assessed for anti-inflammatory and anti-cancer activities by targeting two important enzymes of the arachidonic acid metabolism. Both lipoxygenase and cyclooxygenase enzymes play vital role in c
Attempted Simmon-Smith reaction on β-alkylthio-α,β- unsaturated ketones: A regiospecific synthesis of 2,4-disubstituted thiophenes
Swaroop, Toreshettahally R.,Roopashree, Rangaswamy,Ila, Hiriyakkanavar,Rangappa, Kanchugarakoppal S.
, p. 147 - 150 (2013/02/21)
A new regiospecific route to 2,4-disubstituted thiophenes has been developed through Simmon-Smith reaction on β-methylthio-α,β- unsaturated ketones. Extension of the reaction to β-ethyl/benzylthio- α,β-unsaturated ketones also gave the corresponding 2,4-disubstituted thiophenes in a regiospecific manner. A probable mechanism involving a carbenoid methylene insertion to divalent sulfur followed by intramolecular aldol condensation has been suggested.
