141632-22-6 Usage
Description
3-(2-chlorophenyl)cyclohexanone is an organic compound that features a cyclohexanone core with a chlorophenyl group attached at the 3-position. This molecule is known for its potential applications in the pharmaceutical and chemical industries due to its unique structural properties.
Uses
Used in Pharmaceutical Industry:
3-(2-chlorophenyl)cyclohexanone is used as a key intermediate in the synthesis of tetrahydrobenzimidazole and pyrroloimidazole derivatives. These derivatives have been found to be potent and selective agonists for the α1A adrenergic receptor, which makes them valuable in the development of drugs targeting various medical conditions related to the adrenergic system.
Used in Chemical Synthesis:
In the field of chemical synthesis, 3-(2-chlorophenyl)cyclohexanone can be utilized as a building block for the creation of more complex molecules with diverse applications. Its unique structure allows for further functionalization and modification, making it a versatile compound for researchers and chemists working on new molecular designs.
Check Digit Verification of cas no
The CAS Registry Mumber 141632-22-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,6,3 and 2 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 141632-22:
(8*1)+(7*4)+(6*1)+(5*6)+(4*3)+(3*2)+(2*2)+(1*2)=96
96 % 10 = 6
So 141632-22-6 is a valid CAS Registry Number.
141632-22-6Relevant articles and documents
4,8-disubstituted bicyclo[3.3.1]nona-2,6-dienes as chiral ligands for rh-catalyzed asymmetric 1,4-addition reactions
Rimkus, Renaldas,Jurgelenas, Marius,Ston?ius, Sigitas
supporting information, p. 3017 - 3021 (2015/05/13)
C2-symmetric chiral diene ligands based on 4,8-endo,endo-disubstituted bicyclo[3.3.1]nona-2,6-diene framework have been designed and synthesized. The rhodium complexes of the dienes, which were obtained in a few straightforward steps from enantiomerically pure bicyclo[3.3.1]nonane-2,6-dione, exhibited excellent catalytic activity and high enantioselectivity (up to 96% ee) in the conjugate addition reaction of arylboronic acids to cyclic enones under mild reaction conditions with high atom efficiency. Chiral C2-symmetric 4,8-endo,endo-disubstituted bicyclo[3.3.1]nona-2,6-diene ligands were synthesized from easily available bicyclo[3.3.1]nonane-2,6-dione and utilized in the asymmetric 1,4-addition reaction of arylboronic acids to cyclic enones. The catalyst prepared in situ from ligand 4b and [RhCl(C2H4)2]2 exhibited excellent catalytic activity and high enantioselectivity (up to 96% ee) under mild reaction conditions with high atom efficiency.
