1416352-98-1

Basic information

• Product Name: 4-methyl-N-(2-(2-phenyl-1H-indol-3-yl)-ethyl)benzenesulfonamide
• Synonyms: 4-methyl-N-(2-(2-phenyl-1H-indol-3-yl)-ethyl)benzenesulfonamide
• CAS NO: 1416352-98-1
• Molecular Weight: 390.506
• Mol File: 1416352-98-1.mol

Chemical Properties

• CAS DataBase Reference: 4-methyl-N-(2-(2-phenyl-1H-indol-3-yl)-ethyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-N-(2-(2-phenyl-1H-indol-3-yl)-ethyl)benzenesulfonamide(1416352-98-1)
• EPA Substance Registry System: 4-methyl-N-(2-(2-phenyl-1H-indol-3-yl)-ethyl)benzenesulfonamide(1416352-98-1)

Safety Data

• Hazardous Substances Data: 1416352-98-1(Hazardous Substances Data)

Upstream product

• 948-65-2 2-phenyl-indole 
• 3634-89-7 N-(p-toluenesulfonyl)aziridine 
• 1217-80-7 2-(2-phenyl-1H-indol-3-yl)ethylamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 192182-30-2 2-(2-(2-phenyl-1H-indol-3-yl)ethyl)isoindoline-1,3-dione 
• 192182-46-0 2-(2-(2-bromo-1H-indol-3-yl)ethyl)isoindoline-1,3-dione 
• 15741-71-6 N-phthalimidotryptamine 
• 61-54-1 tryptamine 

Downstream Products

• 1616347-90-0 2-phenyl-2'-methylene-1'-tosylspiro[indole-3,4'-piperidine] 

Relevant articles and documents

Exploiting the σ-phylic properties of cationic gold(i) catalysts in the ring opening reactions of aziridines with indoles

A study on the SN2-type ring opening reactions of aziridines with indoles as nucleophiles is reported. Under gold(i) catalysis a great variety of tryptamine derivatives were prepared in good to excellent yields with complete stereocontrol when chiral aziridines were used. We demonstrated that cationic gold(i) catalysts are superior Lewis acids to the previously reported group 3, 12 and 13 metals in terms of catalyst loading and reaction yields. Moreover, complete regioselectivity was observed for 2-phenyl-N-tosylaziridine; whereas, regioselectivity up to 10:1 ratio was observed with 2-methyl-N-tosylaziridine. Finally, a preliminary study on the dearomatization reactions giving rise to pyrroloindolines is also reported.

Rapid access to spirocyclized indolenines via palladium-catalyzed cascade reactions of tryptamine derivatives and propargyl carbonate

We report the intermolecular palladium-catalyzed reaction of tert-butyl propargyl carbonate with tryptamine derivatives or other indole-containing bis-nucleophiles. The reaction proceeds under mild conditions and with low catalyst loadings to afford novel spiroindolenine products in good to high yields.