1416440-23-7 Usage
Description
6-bromo-3-iodoquinoline is a heterocyclic chemical compound with the molecular formula C9H5BrIN. It features a quinoline ring substituted with bromine at the 6th position and iodine at the 3rd position. 6-bromo-3-iodoquinoline is known for its versatile reactivity and presence in biologically active molecules, making it a valuable building block in the synthesis of pharmaceuticals and agrochemicals. It also serves as an important intermediate in organic synthesis for creating complex molecular structures with potential applications in drug development and materials science. However, it is crucial to handle this compound with care due to its potential health and environmental risks if mismanaged.
Uses
Used in Pharmaceutical Industry:
6-bromo-3-iodoquinoline is used as a building block for the synthesis of various pharmaceuticals, leveraging its versatile reactivity and presence in biologically active compounds. It contributes to the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 6-bromo-3-iodoquinoline is utilized as a key component in the synthesis of agrochemicals, such as pesticides and herbicides. Its unique structure and reactivity enable the creation of effective compounds for crop protection and management.
Used in Organic Synthesis:
6-bromo-3-iodoquinoline serves as a valuable intermediate in organic synthesis, facilitating the construction of complex molecular structures. It is particularly useful in the development of advanced materials and drug candidates with potential applications in various fields, including medicine, chemistry, and materials science.
Used in Drug Development:
6-bromo-3-iodoquinoline plays a significant role in drug development, where it is employed to create novel drug candidates with enhanced efficacy and selectivity. Its presence in biologically active molecules makes it an attractive starting point for the design and synthesis of new therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 1416440-23-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,1,6,4,4 and 0 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1416440-23:
(9*1)+(8*4)+(7*1)+(6*6)+(5*4)+(4*4)+(3*0)+(2*2)+(1*3)=127
127 % 10 = 7
So 1416440-23-7 is a valid CAS Registry Number.
1416440-23-7Relevant articles and documents
Structural Simplification of Bedaquiline: the Discovery of 3-(4-(N,N-Dimethylaminomethyl)phenyl)quinoline-Derived Antitubercular Lead Compounds
He, Chunxian,Preiss, Laura,Wang, Bin,Fu, Lei,Wen, Hui,Zhang, Xiang,Cui, Huaqing,Meier, Thomas,Yin, Dali
supporting information, p. 106 - 119 (2017/02/05)
Bedaquiline (BDQ) is a novel and highly potent last-line antituberculosis drug that was approved by the US FDA in 2013. Owing to its stereo-structural complexity, chemical synthesis and compound optimization are rather difficult and expensive. This study
Metal-free synthesis of N-fused heterocyclic iodides via C-H functionalization mediated by tert-butylhydroperoxide
Sharma, Krishna K.,Patel, Dhananjay I.,Jain, Rahul
supporting information, p. 15129 - 15132 (2015/10/12)
Direct, regioselective and metal-free synthesis of fused N-heterocyclic iodides is reported. This regioselective C-H functionalization is mediated by tert-butylhydroperoxide (TBHP), via dual activation of molecular iodine and a heterocyclic substrate, resulting in the in situ generation of electrophilic iodine species (I+), and free radical(s) tBuO? or tBuOO?, driving the iodination reaction.
The regioselective iodination of quinolines, quinolones, pyridones, pyridines and uracil
Dutta, Uttam,Deb, Arghya,Lupton, David W.,Maiti, Debabrata
supporting information, p. 17744 - 17747 (2015/12/18)
A radical based direct C-H iodination protocol for quinolines, quinolones, pyridones, pyridines, and uracil has been developed. The iodination occurs in a C3 selective manner for quinolines and quinolones. Pyridones and pyridines undergo C3 and C5 iodination, while dimethyl uracil undergoes C5 iodination. Scope of the method was demonstrated through the rapid synthesis of both electron rich as well as electron poor heteroaromatic iodides. The protocol was found to be scalable and general, while a mechanism has been proposed.
