1416446-20-2Relevant academic research and scientific papers
Synthesis and antithrombotic evaluation of novel dabigatran prodrugs containing a cleavable moiety with anti-platelet activity
Yang, Xiao-Zhi,Yang, Wen-Hui,Xu, Yun-Gen,Diao, Xiao-Juan,He, Guang-Wei,Gong, Guo-Qing
, p. 21 - 28 (2012)
A novel series of prodrugs consisting of dabigatran and 2-hydroxymethyl-3,5,6-trimethylpyrazine (HTMP) were synthesized. The pharmacological results show that all of them possess the effect of anti-platelet aggregation induced by thrombin in vitro. Moreover, one of those compounds, Y-2 (ED50 = 2.1 ± 1.3 mg/kg) shows more potent activity for inhibiting thrombosis in vivo than that of dabigatran etexilate (ED50 = 4.4 ± 2.2 mg/kg).
