1416453-34-3

Basic information

• Product Name: (3S)-3,4-dihydro-3-methyl-1-[N-phthaloyl-3-cyclohexyl-(S)-alanyl]-2H-[1,4]benzoxazine
• Synonyms: (3S)-3,4-dihydro-3-methyl-1-[N-phthaloyl-3-cyclohexyl-(S)-alanyl]-2H-[1,4]benzoxazine
• CAS NO: 1416453-34-3
• Molecular Weight: 432.519
• Mol File: 1416453-34-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3S)-3,4-dihydro-3-methyl-1-[N-phthaloyl-3-cyclohexyl-(S)-alanyl]-2H-[1,4]benzoxazine(CAS DataBase Reference)
• NIST Chemistry Reference: (3S)-3,4-dihydro-3-methyl-1-[N-phthaloyl-3-cyclohexyl-(S)-alanyl]-2H-[1,4]benzoxazine(1416453-34-3)
• EPA Substance Registry System: (3S)-3,4-dihydro-3-methyl-1-[N-phthaloyl-3-cyclohexyl-(S)-alanyl]-2H-[1,4]benzoxazine(1416453-34-3)

Safety Data

• Hazardous Substances Data: 1416453-34-3(Hazardous Substances Data)

Upstream product

• 1416453-17-2 N-phthaloyl-3-cyclohexyl-(S)-alanyl chloride 
• 32329-20-7 (RS)-3-methyl-3,4-dihydro-2H-[1,4]benzoxazine 

Relevant articles and documents

Acylative kinetic resolution of racemic heterocyclic amines using N-phthaloyl-(S)-amino acyl chlorides with alkyl side chains

A comparative study of the acylative kinetic resolution of racemic 2-methyl-1,2,3,4 tetrahydroquinoline and 3,4-dihydro-3-methyl-2H-[1,4] benzoxazine using N-phthaloyl-(S)-amino acyl chlorides with alkyl side chains has been carried out. The influence of steric factors on the stereoselectivity of the acylation was demonstrated. The (S)-enantiomers of the heterocyclic amines (ee >99%) were obtained in good yields via a kinetic resolution protocol using N-phthaloyl-(S)-leucyl chloride.