1416565-70-2Relevant academic research and scientific papers
Catalytic asymmetric friedel-crafts reaction of activated phenols and 4-oxo-4-arylbutenoates
Bai, Sha,Liu, Xiaohua,Wang, Zhen,Cao, Weidi,Lin, Lili,Feng, Xiaoming
supporting information, p. 2096 - 2100 (2012/11/07)
A highly enantioselective Friedel-Crafts reaction of activated phenols with (E)-4-oxo-4-arylbutenoates has been developed with the N,N'-dioxide- scandium(III) complex as the catalyst. A variety of (E)-4-oxo-4-arylbutenoates were found to be suitable substrates for the reaction. The desired products were obtained in moderate to high yields (up to 98%) and excellent enantioselectivities (up to 97% ee). Copyright
