1416575-66-0Relevant academic research and scientific papers
Toward polynuclear Ru-Cu catalytic dehydrogenative C-N bond formation, on the reactivity of carbazoles
Louillat, Marie-Laure,Patureau, Frederic W.
, p. 164 - 167 (2013)
The cooperative action of Ru and Cu catalysts enables direct polynuclear C-H and N-H activation for the dehydrogenative N-carbazolation of carbazoles, selectively at the C1 position. Initial mechanistic experiments are presented and discussed.
Accelerated Ru–Cu Trinuclear Cooperative C?H Bond Functionalization of Carbazoles: A Kinetic and Computational Investigation
Jones, Alexander W.,Rank, Christian K.,Becker, Yanik,Malchau, Christian,Funes-Ardoiz, Ignacio,Maseras, Feliu,Patureau, Frederic W.
, p. 15178 - 15184 (2018)
The mechanism of a trinuclear cooperative dehydrogenative C?N bond-forming reaction is investigated in this work, which avoids the use of chelate-assisting directing groups. Two new highly efficient Ru/Cu co-catalyzed systems were identified, allowing orders of magnitude greater TOFs than the previous state of the art. In-depth kinetic studies were performed in combination with advanced DFT calculations, which reveal a decisive rate-determining trinuclear Ru–Cu cooperative reductive elimination step (CRE).
