1416656-01-3Relevant academic research and scientific papers
Synthesis of P-stereogenic phospholene boranes via asymmetric deprotonation and ring-closing metathesis
Wu, Xiao,O'Brien, Peter,Ellwood, Simon,Secci, Francesco,Kelly, Brian
supporting information, p. 192 - 195 (2013/03/28)
The first examples of the asymmetric synthesis of P-stereogenic vinylic phospholene boranes are described. The synthetic approach is concise and flexible. The route involves (i) asymmetric deprotonation-allylation of a dimethyl phosphine borane; (ii) telescoped regioselective deprotonation, paraformaldehyde trapping, and hydroxyl group elimination to give a diene; and (iii) ring-closing metathesis.
