141666-88-8Relevant articles and documents
(+)-Dehydroabietylamine derivatives target triple-negative breast cancer
Ling, Taotao,Tran, My,González, Miguel A.,Gautam, Lekh Nath,Connelly, Michele,Wood, Rachael K.,Fatima, Iram,Miranda-Carboni, Gustavo,Rivas, Fatima
, p. 9 - 13 (2015)
Breast cancer remains the leading cause of cancer-related death among women. The invasive triple-negative subtype is unresponsive to estrogen therapy, and few effective treatments are available. In search of new chemical scaffolds to target this disease,
Covenient Halodeamination and Hydrodeamination of Primary Amines
Guziec, Frank S.,Wei, Dongchu
, p. 3772 - 3776 (2007/10/02)
Treatment of p-toluenesulfonamides of primary amines with 2 equiv of chloroamine at room temperature in the presence of base leads to reductive deamination.If excess chloroamine is present, the corresponding alkyl or aryl halides are obtained instead in good yields.Both reactions presumably proceed via tosylhydrazine and diazene intermediates; the course of the reaction is often governed by steric hindrance.Treatment of the isolated tosylhydrazine intermediate with base and chloroamine, bromine, or iodine also leads to the corresponding halides in very good yields.
