1416792-20-5Relevant articles and documents
18F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease
Calamai, Elisa,Dall'Angelo, Sergio,Koss, David,Domarkas, Juozas,McCarthy, Timothy J.,Mingarelli, Marco,Riedel, Gernot,Schweiger, Lutz F.,Welch, Andy,Platt, Bettina,Zanda, Matteo
supporting information, p. 792 - 794 (2013/02/23)
Three fluoro-barbiturates were synthesised, showing in vivo sedative efficacy. One of them, [18F]1a, was synthesised in radiofluorinated form. PET/CT Imaging with [18F]1a identified β-amyloid over-expressing transgenic mice (βA mice) compared to wild type and tau lines. The fluorescent barbiturate 9 was able to label βA plaques in brain sections of βA mice, and co-localise with a fluorescent Zn(ii) indicator.
