1416913-16-0Relevant articles and documents
Asymmetric vinylogous aldol reaction via H-bond-directing dienamine catalysis
Bastida, David,Liu, Yankai,Tian, Xu,Escudero-Adan, Eduardo,Melchiorre, Paolo
, p. 220 - 223 (2013)
The enantioselective direct vinylogous aldol reaction of 3-methyl 2-cyclohexen-1-one with α-keto esters has been developed. The key to success was the design of a bifunctional primary amine-thiourea catalyst that can combine H-bond-directing activation and dienamine catalysis. The simultaneous dual activation of the two reacting partners results in high reactivity while securing high levels of stereocontrol.