1416952-68-5

Basic information

• Product Name: (S)-1-(4-chloro-phenyl)-2-{4-[(S)-1-hydroxy-1-(1-oxo-hexahydro-1-thiopyran-4-yl)-ethyl]-phenyl}-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one
• Synonyms: (S)-1-(4-chloro-phenyl)-2-{4-[(S)-1-hydroxy-1-(1-oxo-hexahydro-1-thiopyran-4-yl)-ethyl]-phenyl}-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one
• CAS NO: 1416952-68-5
• Molecular Weight: 582.161
• Mol File: 1416952-68-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-1-(4-chloro-phenyl)-2-{4-[(S)-1-hydroxy-1-(1-oxo-hexahydro-1-thiopyran-4-yl)-ethyl]-phenyl}-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(4-chloro-phenyl)-2-{4-[(S)-1-hydroxy-1-(1-oxo-hexahydro-1-thiopyran-4-yl)-ethyl]-phenyl}-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one(1416952-68-5)
• EPA Substance Registry System: (S)-1-(4-chloro-phenyl)-2-{4-[(S)-1-hydroxy-1-(1-oxo-hexahydro-1-thiopyran-4-yl)-ethyl]-phenyl}-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one(1416952-68-5)

Safety Data

• Hazardous Substances Data: 1416952-68-5(Hazardous Substances Data)

Upstream product

• 887481-48-3 1-(1-oxo-hexahydro-1-thiopyran-4-yl)-ethanone 
• 1416952-66-3 (S)-1-(4-chloro-phenyl)-2-{4-[1-hydroxy-1-(1-oxo-hexahydro-1-thiopyran-4-yl)-ethyl]-phenyl}-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one 
• 1313365-55-7 (4-isopropoxy-5-methoxy-2-{[(E)-(S)-2-methyl-propane-2-sulfinylimino]-methyl}-phenyl)-acetic acid ethyl ester 
• 1313365-56-8 {2-[(S)-(4-chloro-phenyl)-((S)-2-methyl-propane-2-sulfinylamino)-methyl]-4-isopropoxy-5-methoxy-phenyl}-acetic acid ethyl ester 
• 1313365-57-9 (S)-1-(4-chloro-phenyl)-7-isopropoxy-6-methoxy-1,4-dihydro-2H-isoquinolin-3-one 
• 1416910-11-6 1-(4-bromo-phenyl)-1-(1-oxo-hexahydro-1-thiopyran-4-yl)-ethanol 
• 1313365-54-6 (2-formyl-4-isopropoxy-5-methoxy-phenyl)-acetic acid ethyl ester 
• 1256581-66-4 (4-isopropoxy-3-methoxy-phenyl)-acetic acid ethyl ester 
• 60563-13-5 ethyl homovanillate 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 4526-07-2 1,4-bis(trimethylsilyl)-1,3-butadiyne 
• 589-87-7 1,4-bromoiodobenzene 
• 14064-15-4 (4-chlorophenyl)trimethylstannane 

Relevant articles and documents

Linkage effects of linear D-π-A-π-D type diketopyrrolopyrrole- triphenylamine based solution-processable organic small molecule photovoltaic materials

Four novel D-π-A-π-D-type small molecules (SMs) were synthesized and their π-linkage effects were investigated. Among them, SM2 with vinylene as the π-linkage exhibited better molecular coplanarity, reaching a relatively higher power conversion efficiency (PCE) of 3.76%. SM3 and SM4 with acetylene and acrylonitrile as π-linkages exhibited relatively higher open-circuit voltages (VOC) of 0.93 V and 0.90 V, respectively, owing to their deep-lying HOMO levels. These results gave an important guide for developing new materials in solution-processed small molecule solar cells.

HYDROXY SUBSTITUTED ISOQUINOLINONE DERIVATIVES

The invention relates to compounds of formula (I): as defined in the application. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.