1417034-40-2Relevant academic research and scientific papers
Regioselective C-H bond cleavage/alkyne insertion under ruthenium catalysis
Hashimoto, Yuto,Hirano, Koji,Satoh, Tetsuya,Kakiuchi, Fumitoshi,Miura, Masahiro
, p. 638 - 646 (2013/03/29)
The ruthenium-catalyzed coupling reactions of benzamides with alkynes in the presence of acetic acid as a promoter smoothly proceeded regio- and stereoselectively through a directed C-H bond cleavage to produce the corresponding ortho-alkenylated products. Phenylpyrazoles and related substrates also underwent a similar coupling to give dialkenylated products selectively. Several competitive experiments were performed to obtain mechanistic insight into both the mono- and dialkenylation reactions.
