1417159-40-0

Basic information

• Product Name: (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)pent-4-ynamido)-4-methylpentanoic acid
• Synonyms: (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)pent-4-ynamido)-4-methylpentanoic acid
• CAS NO: 1417159-40-0
• Molecular Weight: 360.41
• Mol File: 1417159-40-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)pent-4-ynamido)-4-methylpentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)pent-4-ynamido)-4-methylpentanoic acid(1417159-40-0)
• EPA Substance Registry System: (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)pent-4-ynamido)-4-methylpentanoic acid(1417159-40-0)

Safety Data

• Hazardous Substances Data: 1417159-40-0(Hazardous Substances Data)

Upstream product

• 869116-13-2 Cbz-L-propargylglycine-OH 
• 1417159-39-7 methyl (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)pent-4-ynamido)-4-methylpentanoate 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 1443654-61-2 1-((1-methoxy-4-methyl-1-oxopentan-2-yl)amino)-1-oxopent-4-yn-2-aminium chloride 
• 208709-89-1 methyl 2-(2-((tert-butoxycarbonyl)amino)pent-4-ynamido)-4-methylpentanoate 
• 2666-93-5 (S)-Leu-OMe 

Downstream Products

• 1417159-36-4 methyl (6S,9S,12S)-12-(((benzyloxy)carbonyl)amino)-9-isobutyl-8,11-dioxo-1,7,10,15,16-pentaazabicyclo[12.2.1]heptadeca-14⁽¹⁷⁾,15-diene-6-carboxylate 
• 1417159-37-5 benzyl ((6S,9S,12S)-6-(hydroxymethyl)-9-isobutyl-8,11-dioxo-1,7,10,15,16-pentaazabicyclo[12.2.1]heptadeca-14⁽¹⁷⁾,15-dien-12-yl)carbamate 
• 1417159-38-6 benzyl ((6S,9S,12S)-6-formyl-9-isobutyl-8,11-dioxo-1,7,10,15,16-pentaazabicyclo[12.2.1]heptadeca-14⁽¹⁷⁾,15-dien-12-yl)carbamate 
• 1417159-41-1 methyl (5S,8S,11S)-11-(4-azidobutyl)-8-isobutyl-3,6,9-trioxo-1-phenyl-5-(prop-2-yn-1-yl)-2-oxa-4,7,10-triazadodecan-12-oate 
• 1443654-64-5 methyl 11-(3-((3-azidopropyl)amino)-3-oxopropyl)-8-isobutyl-3,6,9-trioxo-1-phenyl-5-(prop-2-yn-1-yl)-2-oxa-4,7,10-triazadodecan-12-oate 

Relevant articles and documents

Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies

Outbreaks of acute gastroenteritis caused by noroviruses constitute a public health concern worldwide. To date, there are no approved drugs or vaccines for the management and prophylaxis of norovirus infections. A potentially effective strategy for the development of norovirus therapeutics entails the discovery of inhibitors of norovirus 3CL protease, an enzyme essential for noroviral replication. We describe herein the structure-based design of the first class of permeable, triazole-based macrocyclic inhibitors of norovirus 3C-like protease, as well as pertinent X-ray crystallographic, biochemical, spectroscopic, and antiviral studies.

MACROCYCLIC AND PEPTIDOMIMETIC COMPOUNDS AS BROAD-SPECTRUM ANTIVIRALS AGAINST 3C OR 3C-LIKE PROTEASES OF PICORNAVIRUSES, CALICIVIRUSES AND CORONAVIRUSES

Antiviral protease inhibitors, including macrocylic transition state inhibitors and peptidomimetics are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection and disease. The compounds possess broad-spectrum activity against viruses that belong to the picornavirus-like supercluster, which include important human and animal pathogens including noroviruses, sapoviruses, enteroviruses, poliovirus, foot-and-mouth disease virus, hepatitis A virus, human rhinovirus (cause of common cold), human coronavirus (another cause of common cold), transmissible gastroenteritis virus, murine hepatitis virus, feline infectious peritonitis virus, and severe acute respiratory syndrome coronavirus.