141722-42-1

Basic information

• Product Name: 5-[1-(2-Chloro-phenyl)-meth-(E)-ylidene]-6-methyl-4,5-dihydro-2H-pyridazine-3-thione
• CAS NO: 141722-42-1
• Molecular Weight: 250.752
• Mol File: 141722-42-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-[1-(2-Chloro-phenyl)-meth-(E)-ylidene]-6-methyl-4,5-dihydro-2H-pyridazine-3-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[1-(2-Chloro-phenyl)-meth-(E)-ylidene]-6-methyl-4,5-dihydro-2H-pyridazine-3-thione(141722-42-1)
• EPA Substance Registry System: 5-[1-(2-Chloro-phenyl)-meth-(E)-ylidene]-6-methyl-4,5-dihydro-2H-pyridazine-3-thione(141722-42-1)

Safety Data

• Hazardous Substances Data: 141722-42-1(Hazardous Substances Data)

Upstream product

• 90060-93-8 5-(2-Chlorobenzylidene)-6-methyl-(4H)-pyridazin-3-on 

Downstream Products

• 141722-60-3 {5-[1-(2-Chloro-phenyl)-meth-(E)-ylidene]-6-methyl-4,5-dihydro-pyridazin-3-ylsulfanyl}-acetic acid 
• 141722-48-7 {5-[1-(2-Chloro-phenyl)-meth-(E)-ylidene]-6-methyl-4,5-dihydro-pyridazin-3-ylsulfanyl}-acetic acid ethyl ester 

Relevant articles and documents

Synthesis and aldose reductase inhibitory activity of pyridazine derivatives possessing acetic acid group

N-acetic acid and S-acetic acid derivatives of 5-arylidene pyridazines were synthesized for evaluation as new aldose reductase inhibitors. Intrinsic activity for each compound was assessed by measuring inhibition of enzymatic activity in an isolated pig lens enzyme preparation. All prepared compounds exhibited a significant in vitro aldose reductase inhibitory effect (10-5 M ≤ IC50 ≤ 10-4 M). It was found that lipophilicity was important in increasing activity. Furthermore, this activity (log l/IC50) could be correlated directly to a lipophilic parameter (log kw) for the whole data set.