141727-48-2

Upstream product

• 780-25-6 N-benzylidene benzylamine 
• 74-88-4 methyl iodide 
• 141727-37-9 3-Benzyl-5-fluoro-2-phenyl-thiazolidin-4-one 
• 141727-43-7 3-Benzyl-5-fluoro-1,1-dioxo-2-phenyl-1λ⁶-thiazolidin-4-one 
• 80353-43-1 3-benzyl-2-phenyl-1,3-thiazolidin-4-one 

Relevant academic research and scientific papers

Direct and diastereoselective alkylation and aldol reactions of α-bromo-α-fluoro-β-lactams

Herein, we describe the development of a method for the direct alkylation and aldol reaction of α-bromo-α-fluoro-β-lactams. This method provides facile access to a wide range of 3-alkyl- and 3-hydroxyalkyl-fluoro- β-lactams in good yields under mild conditions. The products were obtained with complete diastereoselectivity with regard to the relative configuration of the β-lactam ring at C3 and C4 positions. The reaction conditions were tolerant of a broad range of electrophiles, which highlights the overall scope and utility of this procedure.

Electrolytic Partial Fluorination of Organic Compounds. 4. Regioselective Anodic Monofluorination of 4-Thiazolidinones and Its Application to the Synthesis of Monofluoro β-Lactams

Anodic partial fluorination of sulfur-containing heterocycles has been performed for the first time: 2-aryl-4-thiazolidinones 1 were monofluorinated highly regioselectively.In addition, thermolysis of the sulfones derived from fluorinated 1 provided monof