141735-59-3Relevant academic research and scientific papers
Synthesis of (+)-Disparlure Using the Reaction of 6-Methylheptyl Phenyl Sulfone with Trimethylsilyloxirane and Asymmetric Epoxidation
Marczak, Stanislaw,Masnyk, Marek,Wicha, Jerzy
, p. 345 - 347 (2007/10/02)
Reaction of lithiated sulfone 3 with trimethyl(oxiranyl)silane 4, followed by acid hydrolysis, afforded the (Z)-allylic alcohol 6 contaminated with its (E) isomer.Epoxidation of 6 by the Sharpless procedure yielded the hydroxy epoxide, which was isolated as its enantiomerically pure 3,5-dinitrobenzoyl derivative 7 and transformed into (+)-disparlure 1 via alcohol 8 and tosylate 9.
