1417402-96-0

Basic information

• Product Name: N-(4'-fluorobenzenesulfonyl)-3,7-dioxo-5β-cholan-24-amine
• CAS NO: 1417402-96-0
• Molecular Weight: 531.732
• Mol File: 1417402-96-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4'-fluorobenzenesulfonyl)-3,7-dioxo-5β-cholan-24-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4'-fluorobenzenesulfonyl)-3,7-dioxo-5β-cholan-24-amine(1417402-96-0)
• EPA Substance Registry System: N-(4'-fluorobenzenesulfonyl)-3,7-dioxo-5β-cholan-24-amine(1417402-96-0)

Safety Data

• Hazardous Substances Data: 1417402-96-0(Hazardous Substances Data)

Upstream product

• 128-13-2 ursodeoxycholic acid 
• 1417402-85-7 3,7-dioxo-24-cholanyl methansulfonate 
• 1417402-84-6 3,7-dioxo-5β-cholan-24-ol 
• 1417402-83-5 3,7-dioxo-24-triphenylmethoxy-5β-cholane 
• 23848-46-6 UDC-OH 

Relevant articles and documents

Synthesis and antitumor activity of N-sulfonyl-3,7-dioxo-5β-cholan-24- amides, ursodeoxycholic acid derivatives

A series of N-sulfonyl-3,7-dioxo-5β-cholan-24-amides, ursodeoxycholic acid derivatives, have been designed and synthesized in nine steps starting from ursodeoxycholic acid. The in vitro antitumor activity of the target compounds has been evaluated against HCT-116, MCF-7, K562, and SGC-7901 cell lines. The pharmacological results showed that most of the prepared compounds display excellent selective cytotoxicity toward HCT-116, MCF-7, and K562 cell lines. Particularly, compounds 10c, 10f and 10g show high inhibitory activity on these human cancer cell lines (IC50: 2.39-9.34 μM). Conversely, all compounds are generally inactive against SGC-7901, with only 10b having IC50 below 50 μM.