1417539-19-5

Basic information

• Product Name: (3S,28S)-3-O-acetyl-28-[3-(dicyclohexylamino)prop-1-yn-1-yl]lup-20⁽²⁹⁾-en-3,28-diol hydrochloride
• Synonyms: (3S,28S)-3-O-acetyl-28-[3-(dicyclohexylamino)prop-1-yn-1-yl]lup-20⁽²⁹⁾-en-3,28-diol hydrochloride
• CAS NO: 1417539-19-5
• Molecular Weight: 738.578
• Mol File: 1417539-19-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3S,28S)-3-O-acetyl-28-[3-(dicyclohexylamino)prop-1-yn-1-yl]lup-20⁽²⁹⁾-en-3,28-diol hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,28S)-3-O-acetyl-28-[3-(dicyclohexylamino)prop-1-yn-1-yl]lup-20⁽²⁹⁾-en-3,28-diol hydrochloride(1417539-19-5)
• EPA Substance Registry System: (3S,28S)-3-O-acetyl-28-[3-(dicyclohexylamino)prop-1-yn-1-yl]lup-20⁽²⁹⁾-en-3,28-diol hydrochloride(1417539-19-5)

Safety Data

• Hazardous Substances Data: 1417539-19-5(Hazardous Substances Data)

Upstream product

• 27570-21-4 3-O-acetylbetulinal 
• 50-00-0 formaldehyd 
• 101-83-7 N-cyclohexyl-cyclohexanamine 

Relevant articles and documents

Cytotoxic betulin-derived hydroxypropargylamines trigger apoptosis

Several novel betulin derivatives were prepared and evaluated for their antitumor activity. Among others, 3-O-acetylbetulinic aldehyde served as an ideal starting material for the synthesis of 28-acetylenic derivatives that were further transformed into Mannich bases. These hydroxypropargylamines were screened for their antitumor activity in a panel of nine human cancer cell lines in a sulforhodamine B (SRB) assay. Several compounds showed a noteworthy antitumor activity. The results from acridine orange/propidium iodide staining and annexinV-FITC assays as well as DNA laddering experiments provided evidence for an apoptotic cell death.