1417554-79-0Relevant academic research and scientific papers
Synthesis of polysubstituted 1,4-dihydropyridines via three-component reaction
Balalaie, Saeed,Baoosi, Leila,Tahoori, Fatemeh,Rominger, Frank,Bijanzadeh, Hamid Reza
, p. 738 - 743 (2013/07/27)
An efficient one-pot synthesis of novel N-substituted 1,4-dihydropyridine derivatives via a threecomponent reaction of primary amines, dialkyl acetylenedicarboxylates, and methyl (arylmethylidene) pyruvates has been reported. The reaction is performed using ZnCl2 (40 mol %) in dichloroethane in good to high yields through a domino Michael/cyclization sequence. Notably, the ready availability of the starting materials, high bond-forming efficiency, good to high yields and the high level of practicability of the reaction and work up make this approach an attractive complementary method for access to Nsubstituted 1,4-dihydropyridines.
