1417557-72-2

Upstream product

• 1417557-67-5 (3R,4R,6S)-3-azido-4-benzyloxy-6-hydroxyazepane-1-carboxylic acid tert-butyl ester 
• 263889-23-2 (3R,4R)-3-azido-4-benzyloxy-2,3,4,7-tetrahydroazepine-1-carboxylic acid tert-butyl ester 
• 263889-21-0 (3S,4R)-4-benzyloxy-3-hydroxy-2,3,4,7-tetrahydroazepine-1-carboxylic acid tert-butyl ester 
• 263889-20-9 (2S,3R)-allyl-(3-benzyloxy-2-hydroxy-pent-4-enyl)-carbamic acid tert-butyl ester 
• 263889-19-6 (2S,3R)-1-allylamino-3-benzyloxy-pent-4-en-2-ol 
• 110009-21-7 (S)-2-((R)-1-benzyloxy-allyl)-oxirane 

Downstream Products

• 1417557-74-4 (3R,4R,6S)-3-azido-4-benzyloxy-6-fluoroazepane 

Relevant academic research and scientific papers

Conformational regulation of substituted azepanes through selective monofluorination

Substituted azepanes are common bioactive epitopes with flexible ring structures. The conformational effects of monofluorination in model azepane rings were investigated by 1H NMR spectroscopy and computational modelling. A single fluorine atom, installed diastereoselectively, was found to bias the azepane ring to one major conformation for one diastereomer. The Royal Society of Chemistry 2013.

Diastereospecific fluorination of substituted azepanes

Fluorination of bioactive compounds is an important step in drug discovery and development. Fluorination has been extensively studied in acyclic systems, carbocycles, and fused heterocycles. However, there is no report on fluorination of azepanes. As azep