1417564-65-8Relevant articles and documents
Design, synthesis and bioevalution of novel benzamides derivatives as HDAC inhibitors
Li, Yanyang,Zhou, Yan,Qian, Pengyu,Wang, Yongzhen,Jiang, Falong,Yao, Zhenglin,Hu, Wenxiang,Zhao, Yanjin,Li, Shuxin
, p. 179 - 182 (2013/02/23)
A series of novel benzamides derivatives was designed and synthesized as HDAC inhibitors. Exploration of the structure-activity relationships resulted in compounds that are potent in vitro. In addition, the best compound 1a exhibited an acceptable pharmacokinetic profile with bioavailability in rat of 81% and could be considered as a candidate compound for further development.