14176-49-9Relevant articles and documents
Transition-metal-free α-arylation of nitroketones with diaryliodonium salts for the synthesis of tertiary α-aryl, α-nitro ketones
An, Yang,Zhang, Xiao-Ming,Li, Ze-Yu,Xiong, Wen-Hui,Yu, Run-Dong,Zhang, Fu-Min
, p. 119 - 122 (2019/01/03)
Transition-metal-free α-arylation of α-nitroketones with diaryliodonium salts has been realized for the first time. As an application of this methodology, a concise synthesis of the clinical drug tiletamine was also achieved via a three-step procedure from 2-nitrocyclohexanone without the isolation of intermediates.
Sequential [3,3]-Sigmatropic Rearrangement/Nucleophilic Arylation of N -(Benzoyloxy)enamides towards the Preparation of Cyclic β-Aryl-β-amino Alcohols
Sato, Shohei,Takeda, Norihiko,Ueda, Masafumi,Miyata, Okiko
, p. 882 - 892 (2016/03/15)
A new method has been developed for the efficient synthesis of cyclic β-aryl-β-amino alcohol derivatives bearing a tetrasubstituted carbon center via the [3,3]-sigmatropic rearrangement of N-(benzoyl oxy)enamides followed by nucleophilic arylation reactio