141761-85-5

Basic information

• Product Name: Methyl 6-bromo-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylate
• Synonyms: Methyl 6-bromo-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylate;Methyl 6-bromo-3,4-dihydro-3-oxo-2H-1,4-benzoxazine-8-carboxylate 95+%;6-Bromo-3,4-dihydro-8-(methoxycarbonyl)-3-oxo-2H-1,4-benzoxazine;6-Bromo-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxylic acid methyl ester;methyl 6-bromo-3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazine-8-carboxylate
• CAS NO: 141761-85-5
• Molecular Formula: C10H8BrNO4
• Molecular Weight: 286
• Mol File: 141761-85-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl 6-bromo-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 6-bromo-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylate(141761-85-5)
• EPA Substance Registry System: Methyl 6-bromo-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylate(141761-85-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 141761-85-5(Hazardous Substances Data)

Usage

General Description

Methyl 6-bromo-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylate is a chemical compound with the molecular formula C10H8BrNO4. It is a benzoxazine derivative that contains a bromine atom, a carbonyl group, and a methyl ester functional group. Methyl 6-bromo-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylate has potential applications as a building block in the synthesis of pharmaceuticals or other organic compounds. It may also have properties that make it useful in chemical research or industrial processes. However, further specific uses and properties of this compound would need to be determined through additional study and experimentation.

Upstream product

• 141761-82-2 3-amino-5-bromo-2-hydroxybenzoic acid methyl ester 
• 4068-76-2 5-bromo-2-hydroxy-benzoic acid methyl ester 
• 91983-31-2 methyl 5-bromo-2-hydroxy-3-nitrobenzoate 

Downstream Products

• 141761-88-8 6-Bromo-4-methyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis and pharmacology of 3,4-dihydro-3-oxo-1,4-benzoxazine-8-carboxamide derivatives, a new class of potent serotonin-3 (5-HT3) receptor antagonists

A series of 3,4-dihydro-3-oxo-1,4-benzoxazine-8-carboxamide derivatives was synthesized and evaluated for serotonin-3 (5-HT3) receptor antagonistic activity assessed by their ability to antagonize the von Bezold-Jarish (BJ) effect in rats. Derivatives bearing 1-azabicyclo[2.2.2]oct-3-yl moiety as a basic function attached to the carboxamide at position 8 showed more potent antagonistic activity than those bearing the other three basic moieties. Structure activity relationships of this series showed that methyl and chloro groups were more effective as substituents at positions 4 and 6, respectively. The representative compound 15 (Y-25130) in this series showed potent antagonistic activity on the BJ effect (ED50 = 1.3 μg/kg i.v.), high affinity for 5-HT3 receptor (K(i) = 2.9 nM) and complete protection against cisplatin-induced emesis in dogs at a dose of 0.1 mg/kg i.v.