141761-86-6

Basic information

• Product Name: Methyl 6-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylate
• Synonyms: Methyl 6-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylate;Methyl 6-Methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxylate
• CAS NO: 141761-86-6
• Molecular Formula: C11H11NO4
• Molecular Weight: 221
• Mol File: 141761-86-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 431.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.271±0.06 g/cm3(Predicted)
• PKA: 12.20±0.20(Predicted)
• CAS DataBase Reference: Methyl 6-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 6-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylate(141761-86-6)
• EPA Substance Registry System: Methyl 6-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylate(141761-86-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 141761-86-6(Hazardous Substances Data)

Usage

General Description

Methyl 6-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylate is a compound with the molecular formula C12H13NO4. It is a benzoxazine derivative, which is a class of organic compounds containing a benzene ring fused to an oxazine ring. Methyl 6-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylate is commonly used as a building block in organic synthesis and pharmaceutical research. It has potential applications in the development of new drugs and pharmaceutical products due to its unique molecular structure and reactivity. Additionally, it may also have uses in materials science and other industrial applications due to its versatile chemical properties.

Upstream product

• 67191-44-0 methyl 2-hydroxy-5-methyl-3-nitrobenzoate 
• 70978-07-3 methyl 3-amino-2-hydroxy-5-methylbenzoate 
• 22717-57-3 methyl 6-hydroxy-m-toluate 

Downstream Products

• 123040-88-0 4,6-Dimethyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxylic acid 

Relevant articles and documents

Synthesis and pharmacology of 3,4-dihydro-3-oxo-1,4-benzoxazine-8-carboxamide derivatives, a new class of potent serotonin-3 (5-HT3) receptor antagonists

A series of 3,4-dihydro-3-oxo-1,4-benzoxazine-8-carboxamide derivatives was synthesized and evaluated for serotonin-3 (5-HT3) receptor antagonistic activity assessed by their ability to antagonize the von Bezold-Jarish (BJ) effect in rats. Derivatives bearing 1-azabicyclo[2.2.2]oct-3-yl moiety as a basic function attached to the carboxamide at position 8 showed more potent antagonistic activity than those bearing the other three basic moieties. Structure activity relationships of this series showed that methyl and chloro groups were more effective as substituents at positions 4 and 6, respectively. The representative compound 15 (Y-25130) in this series showed potent antagonistic activity on the BJ effect (ED50 = 1.3 μg/kg i.v.), high affinity for 5-HT3 receptor (K(i) = 2.9 nM) and complete protection against cisplatin-induced emesis in dogs at a dose of 0.1 mg/kg i.v.