1417623-59-6

Basic information

• Product Name: 3-(N-PROP-2-YNYLCARBAMOYL)PROP-2-ENOIC ACID
• Synonyms: 3-(N-PROP-2-YNYLCARBAMOYL)PROP-2-ENOIC ACID
• CAS NO: 1417623-59-6
• Molecular Formula: C7H7NO3
• Molecular Weight: 153.14
• Mol File: 1417623-59-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(N-PROP-2-YNYLCARBAMOYL)PROP-2-ENOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(N-PROP-2-YNYLCARBAMOYL)PROP-2-ENOIC ACID(1417623-59-6)
• EPA Substance Registry System: 3-(N-PROP-2-YNYLCARBAMOYL)PROP-2-ENOIC ACID(1417623-59-6)

Safety Data

• Hazardous Substances Data: 1417623-59-6(Hazardous Substances Data)

Downstream Products

• 1417623-60-9 (E)-octyl-4-oxo-4-(prop-2-yn-1-ylamino)but-2-enoate 
• 1417623-61-0 (E)-benzyl-4-oxo-4-(prop-2-yn-1-ylamino)but-2-enoate 

Relevant articles and documents

Clickable, selective, and cell-permeable activity-based probe of human cathepsin B – Minimalistic approach for enhanced selectivity

Human cathepsin B is a cysteine-dependent protease whose roles in both normal and diseased cellular states remain yet to be fully delineated. This is primarily due to overlapping substrate specificities and lack of unambiguously annotated physiological functions. In this work, a selective, cell-permeable, clickable and tagless small molecule cathepsin B probe, KDA-1, is developed and kinetically characterized. KDA-1 selectively targets active site Cys25 residue of cathepsin B for labeling and can detect active cellular cathepsin B in proteomes derived from live human MDA-MB-231 breast cancer cells and HEK293 cells. It is anticipated that KDA-1 probe will find suitable applications in functional proteomics involving human cathepsin B enzyme.