1417703-63-9Relevant academic research and scientific papers
Access to some angular aminochromeno[2,3-c]pyrazole Precursors by a domino knoevenagel-hetero-diels-alder reaction
Parmar, Narsidas J.,Pansuriya, Bhavesh R.,Labana, Balvantsingh M.,Sutariya, Tushar R.,Kant, Rajni,Gupta, Vivek K.
, p. 5953 - 5964,12 (2012)
A new, solvent-free tetrabutylammonium-hydrogensulfate-catalysed one-pot procedure to synthesise angular benzopyran-annulated pyrazoles, all of which incorporate a tertiary ring-junction carbon, has been demonstrated. A typical intermediate Knoevenagel he
Efficient synthesis and biological evaluation of new benzopyran-annulated pyrano[2,3-c]pyrazole derivatives
Labana, Balvantsingh M.,Brahmbhatt, Gaurangkumar C.,Sutariya, Tushar R.,Parmar, Narsidas J.,Padrón, José M.,Kant, Rajni,Gupta, Vivek K.
, p. 339 - 354 (2017/05/29)
Abstract: A one-pot method has been described to synthesize benzopyran-annulated pyrano[2,3-c]pyrazoles, effectively by combining O-alkenyloxy/alkynyloxy-acetophenones with various pyrazolones in triethylammonium acetate (TEAA) under microwave irradiation. While combination of O-allyloxy- or O-prenyloxy-acetophenones with pyrazolones occurred efficiently, that of O-propargyloxy-acetophenones was found effective in the presence of ZnO catalyst, via a domino Knoevenagel–hetero-Diels–Alder (DKHDA) reaction. Aminobenzopyran frameworks were also synthesized, after nitro-containing products were reduced in tandem with iron(II) in an acidic medium. The in vitro antiproliferative activity of these compounds was measured and discussed against gram-positive, gram-negative and M. tuberculosis bacteria, fungi, and various representative human solid tumor cell lines, in addition to their ferric reducing antioxidant capability.
