1417736-75-4

Upstream product

• 937046-98-5 7-bromo-pyrrolo[2,1-f][1,2,4]triazin-4-ylamine 
• 98977-36-7 3-oxo-piperidine-1-carboxylic acid tert-butyl ester 
• 937047-54-6 tert-butyl 3-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3-hydroxypiperidine-1-carboxylate 
• 162744-59-4 (4-bromo-2,6-difluoro-phenyl)methanol 
• 937049-06-4 tert-butyl 3-(4-amino-5-bromopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3-hydroxypiperidine-1-carboxylate 

Downstream Products

• 1417736-06-1 rac-3-{4-amino-5-[3,5-difluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}piperidin-3-ol 

Relevant academic research and scientific papers

HYDROXYMETHYLARYL-SUBSTITUTED PYRROLOTRIAZINES AS ALK1 INHIBITORS

This invention relates to novel 5-[(hydroxymethyl)aryl] -substituted pyrrolo[2, 1-f][1, 2, 4] triazin-4-amines of formula (I), to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating angiogenesis-related disorders, in particular angiogenesis-related ocular disorders.