1417739-75-3Relevant academic research and scientific papers
Enantiopure trifluoromethylated β3,3-amino acids: Synthesis by asymmetric reformatsky reaction with stable analogues of trifluoromethyl N-tert-butanesulfinylketoimines and incorporation into α/β-peptides
Grellepois, Fabienne
, p. 1127 - 1137 (2013)
Addition of a Reformatsky reagent to α-aryl(alkyl) α-trifluoromethyl N-tert-butanesulfinyl hemiaminals, bench-stable surrogates of trifluoromethyl ketoimines, provided β-alkyl(aryl) β-trifluoromethyl β-amino acids derivatives in good yields and high diastereoselectivities. The N-tert-butanesulfinyl β3,3-amino esters were further utilized as versatile intermediates for the elaboration of heterodi- and -tripeptides.
