1417784-04-3Relevant academic research and scientific papers
C7β-methyl analogues of the orvinols: The discovery of kappa opioid antagonists with nociceptin/orphanin FQ peptide (NOP) receptor partial agonism and low, or zero, efficacy at Mu opioid receptors
Cueva, Juan Pablo,Roche, Christopher,Ostovar, Mehrnoosh,Kumar, Vinod,Clark, Mary J.,Hillhouse, Todd M.,Lewis, John W.,Traynor, John R.,Husbands, Stephen M.
, p. 4242 - 4249 (2015)
Buprenorphine is a successful analgesic and treatment for opioid abuse, with both activities relying on its partial agonist activity at mu opioid receptors. However, there is substantial interest in its activities at the kappa opioid and nociceptin/orphan
ORVINOL AND THEVINOL DERIVATIVES USEFUL IN THE TREATMENT OF DRUG AND ALCOHOL ABUSE
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Paragraph 0054; 0061; 0065; 0112; 0114; 0124, (2014/08/07)
The invention provides orvinol and thevinol compounds useful for the treatment of drug and alcohol abuse, the compounds being particularly useful for the prevention of relapse in recovering addicts.
ORVINOL AND THEVINOL DERIVATIVES USEFUL IN THE TREATMENT OF DRUG AND ALCOHOL ABUSE
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Page/Page column 38, (2013/03/26)
The invention provides orvinol and thevinol compounds useful for the treatment of drug and alcohol abuse, the compounds being particularly useful for the prevention of relapse in recovering addicts.
