1417795-99-3

Upstream product

• 1417795-93-7 (1R,2S,4R)-5-(4-methoxybenzyloxy)-1-(furan-2-yl)-2,4-dimethylpentan-1-ol 
• 1417795-95-9 (2R)-2-((2S,4R)-5-(4-methoxybenzyloxy)-4-methylpentan-2-yl)-6-hydroxy-2H-pyran-3(6H)-one 
• 1417796-06-5 (5R,6R)-6-((2S,4R)-5-(4-methoxybenzyloxy)-4-methylpentan-2-yl)-5,6-dihydro-5-hydroxypyran-2-one 
• 1417795-97-1 (2E,4E,6S)-(2R,3R)-2-((2S,4R)-5-(4-methoxybenzyloxy)-4-methylpentan-2-yl)-3,6-dihydro-6-oxo-2H-pyran-3-yl 8-tert-butyldiphenylsilyloxy-6-(tert-butyldiphenylsilyloxy-methyl)-4-methylocta-2,4-dienoate 
• 138499-16-8 2-[(tert-butyldiphenylsilyl)oxy]ethanol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 126822-71-7 1-iodo-2-<(tert-butyldiphenylsilyl)oxy>ethane 
• 1026281-20-8 2-(2-(tert-butyldiphenylsilyloxy)ethyl)propane-1,3-diol 
• 1417795-76-6 (R)-4-(tert-butyldiphenylsilyloxy)-2-(hydroxymethyl)butyl acetate 
• 1417795-77-7 (S)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butyl acetate 
• 1417795-78-8 (S)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butan-1-ol 
• 1417795-79-9 (R)-4-(tert-butyldiphenylsilyloxy)-2-((tert-butyldiphenylsilyloxy)methyl)butanal 
• 1417795-80-2 (S,E)-ethyl-6-(tert-butyldiphenylsilyloxy)-4-((tert-butyldiphenylsilyloxy)methyl)-2-methylhex-2-enoate 
• 1417795-81-3 (S,E)-6-(tert-butyldiphenylsilyloxy)-4-((tert-butyldiphenylsilyloxy)methyl)-2-methylhex-2-enal 

Downstream Products

• 1417796-00-9 (2E,4E,6S)-(2R,3R)-3,6-dihydro-2-((2S,4R)-5-iodo-4-methylpentan-2-yl)-6-oxo-2H-pyran-3-yl 8-tert-butyldiphenylsilyloxy-6-(tert-butyldiphenylsilyloxy-methyl)-4-methylocta-2,4-dienoate 
• 1417796-01-0 (2E,4E,6S)-(2R,3R)-3,6-dihydro-2-((E,2S,4R)-4,6-dimethyloct-6-en-2-yl)-6-oxo-2H-pyran-3-yl 8-tert-butyldiphenylsilyloxy-6-(tert-butyldiphenylsilyloxy-methyl)-4-methylocta-2,4-dienoate 
• 303156-68-5 (-)-(S,2E,4E)-((2R,3R)-2-((2S,4R,E)-4,6-dimethyloct-6-en-2-yl)-6-oxo-3,6-dihydro-2H-pyran-3-yl) 8-hydroxy-6-(hydroxymethyl)-4-methylocta-2,4-dienoate 

Relevant academic research and scientific papers

Asymmetric total synthesis of (-)-rasfonin

An efficient chemoenzymatic asymmetric synthesis of pyranone containing natural product (-)-rasfonin is presented here. Enantioselective enzymatic desymmetrization (EED) and a unique Gluconobacter oxydans mediated oxidative kinetic resolution (OKR) have been successfully employed to install three stereocenters (C6′, C7, and C9) of the target molecule. Stereoselective Achmatowicz reaction of a properly decorated furyl nucleus led to the core pyranone structure of rasfonin. At the late stage of the synthesis Negishi coupling has been used to complete the synthesis.