141783-63-3

Basic information

• Product Name: N-BOC-THIAZOLIDINE-2-CARBOXYLIC ACID
• Synonyms: N-BOC-THIAZOLIDINE-2-CARBOXYLIC ACID;3-(tert-Butoxycarbonyl)thiazolidine-2-carboxylic acid;3-Boc-thiazolidine-2-carboxylic acid
• CAS NO: 141783-63-3
• Molecular Formula: C₉H₁₅NO₄S
• Molecular Weight: 233.2847
• Mol File: 141783-63-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: 95°
• Boiling Point: 385.3±42.0 °C(Predicted)
• Appearance: /
• Density: 1.305±0.06 g/cm3(Predicted)
• PKA: 3.05±0.20(Predicted)
• CAS DataBase Reference: N-BOC-THIAZOLIDINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-THIAZOLIDINE-2-CARBOXYLIC ACID(141783-63-3)
• EPA Substance Registry System: N-BOC-THIAZOLIDINE-2-CARBOXYLIC ACID(141783-63-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 141783-63-3(Hazardous Substances Data)

Usage

Uses

3-(tert-Butoxycarbonyl)thiazolidine-2-carboxylic Acid is a useful reagent for synthesis of non-hydroxamate histone deacetylase inhibitors.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 16310-13-7 DL-3-thiazolidine-4-carboxylic acid 

Downstream Products

• 860495-75-6 2-[5-(phenylcarbamoyl)pentylcarbamoyl]thiazolidine-3-carboxylic acid tert-butyl ester 
• 218943-72-7 N-(4-nitrobenzyl)-3-(t-butoxycarbonyl)thiazolidine-2-carboxamide 
• 104434-80-2 6-(4-(3-tert.-Butoxycarbonyl-thiazolidin-2-yl-carbonyl-amino)-phenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone 
• 218943-76-1 N-(4-{[2-thiazolidinyl]carbonylaminomethyl}phenyl)-2-thiophenecarboximidamide fumarate 

Relevant articles and documents

BIOCONJUGATION OF POLYPEPTIDES

Certain embodiments of the present invention relate to methods of forming and manipulating bioconjugates. Particularly, but not exclusively certain embodiments relate to methods of reversible carbon-carbon bond bioconjugation using aldol based chemical reactions at physiological conditions.

HETEROCYCLE CARBOXAMIDE DERIVATIVES HAVING ADAMANTYL GROUP, PROCESS FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT

The present invention relates to a heterocyclic carboxamide derivative having an adamantyl group represented by chemical formula 1 which inhibits the activity of 11andbeta;-hydroxysteroid dehydrogenase type 1 (11andbeta;-HSD1), a prodrug of the same, a solvate of the same, a stereoisomer or a pharmaceutically acceptable salt of the same, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. In the chemical formula 1, W, X, R_1, R_2, L, a, and b are as defined in the specification of the present invention.COPYRIGHT KIPO 2017

Synthesis and 11β hydroxysteroid dehydrogenase 1 inhibition of thiazolidine derivatives with an adamantyl group

A new series of thiazolidine derivatives with an adamantyl group was synthesized and evaluated for their ability to inhibit 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1). Our initial compound 5a showed a weak inhibitory activity. Significant improvements in potency were achieved by substituent modification. The potent compound 8g (E) showed good in vitro inhibitory activity toward human 11β-HSD1, selectivity toward 11β-HSD2, metabolic stability, pharmacokinetic, and safety profile. Furthermore, this compound significantly inhibited 11β-HSD1 activity in rat and monkey models, and showed improved glycemic control in KKAy mice.