1417888-16-4Relevant articles and documents
One-pot synthesis of pyrrolo[1,2-a]indoles by chiral N-triflyl phosphoramide catalyzed Friedel-Crafts alkylation of 4,7-dihydroindole with β,γ-unsaturated α-keto esters
Zeng, Mi,Zhang, Wei,You, Shuli
, p. 2615 - 2623 (2012)
Chiral N-triflyl phosphoramide was found an efficient catalyst for the enantioselective Friedel-Crafts alkylation reaction of 4,7-dihydroindole with β,γ-unsaturated α-keto esters. In the presence of 5 mol% of the optimized catalyst, various pyrrolo[1,2-a]indoles were obtained in excellent enantioselectivity, moderate yields and up to 3:1 diastereoselectivity based on the one-pot synthesis including the Friedel-Crafts alkylation reaction and the subsequent p-benzoquinone oxidation.