1417907-66-4

Basic information

• Product Name: C₃₁H₄₅NO₅Si
• CAS NO: 1417907-66-4
• Molecular Weight: 539.788
• Mol File: 1417907-66-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₁H₄₅NO₅Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₁H₄₅NO₅Si(1417907-66-4)
• EPA Substance Registry System: C₃₁H₄₅NO₅Si(1417907-66-4)

Safety Data

• Hazardous Substances Data: 1417907-66-4(Hazardous Substances Data)

Upstream product

• 566949-37-9 4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)benzaldehyde 
• 603113-12-8 (5aS,7S)-7-(2-amino-1-methylethyl)-3-methyl-1H,7H-5a,6,8,9-tetrahydro-1-oxopyrano[4,3-b][1]benzopyran 

Downstream Products

• 1402353-95-0 C₂₅H₃₁NO₅ 

Relevant articles and documents

Inhibition of Acyl-CoA: Cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloid β (Aβ) oligomers-induced neuronal cell death by tricyclic pyrone molecules

A major effort in Alzheimers disease therapeutic development has targeted Aβ and downstream events. We have synthesized a small library of tricyclic pyrone compounds. Their protective action in MC65 cells and inhibition of ACAT along with the upregulation of cholesterol transporter gene were investigated. Five active compounds exhibited potencies in the nanomolar ranges. The multiple effects of the compounds on Aβ and cellular cholesterol pathways could be potential mechanisms underlying the protective effects in vivo.