1417995-98-2

Upstream product

• 197230-10-7 (4S)-4-(methoxymethoxy)hept-6-en-1-ol 
• 1417995-96-0 (S)-{[4-(methoxymethoxy)hept-6-enyloxy]methyl}benzene 
• 127793-67-3 (S)‐7‐(benzyloxy)hept‐1‐en‐4‐ol 
• 1417995-97-1 (R)-4-benzyl-3-[(S)-4-(methoxymethoxy)hept-6-enoyl]oxazolidin-2-one 
• 74-88-4 methyl iodide 
• 1258958-40-5 (4S)-4-(methoxymethoxy)hept-6-enoic acid 

Downstream Products

• 1417996-00-9 (5R,7R)-5-allyl-7,11,11-trimethyl-10,10-diphenyl-2,4,9-trioxa-10-siladodecane 
• 1417996-01-0 (4R,6R)-7-(tert-butyldiphenylsilyloxy)-4-(methoxymethoxy)-6-methylheptan-1-ol 
• 1417995-94-8 (4R,6R)-7-(tert-butyldiphenylsilyloxy)-4-(methoxymethoxy)-6-methylheptanal 
• 1417996-06-5 (4R,10R,12R,E)-4-(tert-butyldimethylsilyloxy)-13-(tert-butyldiphenylsilyloxy)-10-(methoxymethoxy)-12-methyltridec-6-enyl pivalate 
• 1417996-07-6 (4R,10R,12R,E)-13-(tert-butyldiphenylsilyloxy)-4-hydroxy-10-(methoxymethoxy)-12-methyltridec-6-enyl pivalate 
• 1417995-93-7 (4R,10R,12R,E)-13-(tert-butyldiphenylsilyloxy)-10-(methoxymethoxy)-12-methyl-4-(methylsulfonyloxy)tridec-6-enyl pivalate 
• 1417995-92-6 3-{(2S,4S,5S)-5-[(3R,5R)-6-(tert-butyldiphenylsilyloxy)-3-(methoxymethoxy)-5-methylhexyl]-4-hydroxytetrahydrofuran-2-yl}propyl pivalate 
• 1417996-08-7 3-{(2S,5S)-5-[(3R,5R)-6-(tert-butyldiphenylsilyloxy)-3-(methoxymethoxy)-5-methylhexyl]-4-oxotetrahydrofuran-2-yl}propyl pivalate 
• 1417995-91-5 3-{(2S,5S)-5-[(3R,5R)-6-(tert-butyldiphenylsilyloxy)-3-(methoxymethoxy)-5-methylhexyl]-4-methylenetetrahydrofuran-2-yl}propyl pivalate 

Relevant academic research and scientific papers

Asymmetric synthesis of the C14-C26 building block of eribulin mesylate

An alternative route for the synthesis of the C14-C26 building block of the anticancer drug eribulin mesylate is described. The key steps involved in the synthesis are a Julia-Kocienski olefination between aldehyde 4 and sulfone 5 and a tandem Sharpless asymmetric dihydroxylation/SN2 cyclisation reaction on mesyl compound 3. Copyright