1418016-85-9

Upstream product

• 459216-72-9 (1R,2S,3S)-1-dimethoxyphosphoryl-2-carbomethoxy-3-phenylcyclopropane 

Downstream Products

• 1418016-86-0 (1R,2S,3S)-dimethoxyphosphoryl-2-formyl-3-phenylcyclopropane 
• 1418016-87-1 (1S,2R,3S,S_S)-N-(2-Dimethoxyphosphoryl)-(3-phenyl)cyclopropylmethylidene-p-toluenesulfinamide 
• 1418016-88-2 (2S,1'S,2'R,3'S,S_S)-[(N-p-toluenesulfinyl)-2-amino]-2-[2'-dimethoxyphosphoryl-3'-phenyl]cyclopropylethanenitrile 
• 1418016-95-1 C₂₀H₂₃N₂O₄PS 

Relevant academic research and scientific papers

Asymmetric synthesis of conformationally constrained L-AP4 analogues using chiral sulfinyl auxiliary

Constrained L-AP4 analogues, (2S,1′R,2′S)- and (2S,1′S,2′R)-2-(2′-phosphonocyclopropyl) glycines as well as their phenyl analogues (2S,1′S,2′R,3′S)-2-(2′-phosphono- 3′-phenylcyclopropyl) glycine (PPCG-1) and (2S,1′R,2′S, 3′R)-2-(2′-phosphono-3′-phenylcyclopropyl) glycine (PPCG-2) were synthesized. The stereogenic centers in cyclopropane ring were formed under sulfinyl group control, in asymmetric cyclopropanation of enantiomerically pure a-phosphoryl vinyl sulfoxides. The sulfinimine-mediated asymmetric Strecker reaction allowed to introduce amino acid moiety.